Theodore DeWeese, M.D.

Interim Dean and CEO, Johns Hopkins Medicine
Department of Radiation Oncology and Molecular Radiation Sciences

The Johns Hopkins University School of Medicine
401 N. Broadway, Suite 1440
Baltimore, MD 21231
Tel:  410-614-3979
Fax:  410-502-7234
Email: deweese@jhmi.edu

The DeWeese laboratory’s research focus is on identifying DNA repair enzymes that, if inactivated, would result in substantial radiation sensitization. Our team has synthesized a chimeric molecule in which a siRNA-targeting DNA repair protein is combined with an aptamer targeting the prostate-unique protein, prostate specific membrane antigen (PSMA). This results in a chimeric siRNA-apatmer that is a potent, targeted radiosensitizer with potential for translation into prostate cancer therapy.

Dr. Alok Mishra

Research Associate
410-503-7062
Amishr13@jhmi.edu

coming soon