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Phuoc Tran Lab


Dr. Tran and his laboratory focus their studies on the transitions between epithelial and mesenchymal cellular states and the implications of these transitions for tumorigenesis, cancer treatment resistance and radiation-induced fibrosis primarily through the use of inducible transgenic mouse models and non-invasive rodent imaging. One of these transitions known as epithelial-mesenchymal transition (EMT) is a conserved developmental program that when inappropriately activated in post-natal life has been associated with organ fibrosis, tumorigenesis and metastasis. A major focus of the laboratory is the use of inducible mouse models to simulate molecularly targeted therapies for malignancies and radiation induced late effects.  Another focus of the laboratory is the study of novel targeted agents as tumor selective radiosensitizers to increase the therapeutic ratio of clinical radiotherapy. 

Clinically Dr. Tran treats patients with cancers of the genitourinary system and uses stereotactic radiation techniques (such as SRS and SBRT/SABR) for the treatment of patients with oligometastatic disease.  The Tran lab is committed to translating discoveries from the laboratory bench into novel cancer prevention, diagnostic, theranostic and treatment approaches that can be tested in the clinic, as evidenced by a number of clinical trials with Dr. Tran as the principal investigator being conducted at Johns Hopkins.

Full List of Publications

Recent Publications (since 2009)

1. Wendy Hara, Phuoc T. Tran, Gordon Li, Zheng Su, Putipun Puataweepong, John Adler, Steven Chang, Scott Soltys and Iris C. Gibbs. Cyberknife for brain metastases of malignant melanoma and renal cell carcinoma. Neurosurgery 64 (2009) A26-32. PMID: 19165071.

2. Melissa Horoschak, Phuoc T. Tran+, Pavan Bachireddy, Robert B. West, David Mohler, Christopher Beaulieu, Daniel S. Kapp, and Sarah S. Donaldson. External beam radiation therapy enhances local control in pigmented villonodular synovitis. Int J Radiat Oncol Biol Phys. 75 (2009) 183-187. PMID: 19211195. + - corresponding author.

3. Christopher H. Chapman, John Shen, Edith J. Filion, Phuoc T. Tran, Wendy Hara, Alfredo Asuncion, Daniel Marko, Heather Wakelee, Gerald J. Berry, Kevin W. Dimmick, Billy W. Loo, Jr., Jon Green. Marked tumor response and fatal hemoptysis during radiation for lung cancer in an HIV-positive patient taking nelfinavir. J Thorac Oncol 4 (2009) 1587-1589. PMID: 20009915.

4. Hu Zhou, Manuel Rodriguez, Fred van den Haak, Geoffrey Nelson, Rahil Jogani, Jiali Xu, Xinzhi Zhu, Yongjiang Xian, Phuoc T. Tran, Dean W. Felsher, Paul J. Keall, Edward E. Graves. Development of a MicroCT-Based Image-Guided Conformal Radiotherapy System for Small Animals. Int J Radiat Oncol Biol 78 (2010)297-305. PMID: 20395069; PMCID: PMC2906632.

5. Edward E. Graves, Marta Vilalta, Ivana K. Cecic, Janine T. Erler, Phuoc T. Tran, Dean Felsher, Leanne Sayles, Alejandro Sweet-Cordero Quynh-Thu Le and Amato J. Giaccia. Hypoxia in models of lung cancer: implications for targeted therapeutics. Clin Cancer Res 16 (2010) 4843-52. PMID: 20858837; PMCID: PMC2948600.

6. Pavan Bachireddy*, Diane Tseng*, Melissa Horoschak, Daniel T. Chang, Albert C. Koong, Daniel S. Kapp, Phuoc T. Tran. Orthovoltage intraoperative radiation therapy for pancreatic adenocarincoma. Radiation Oncology 5 (2010) 105. PMID: 21059255; PMCID: PMC2987939. * - these authors contributed equally.

7. Carsten H. Nielsen, Richard H Kimura, Nadia Withofs, Phuoc T. Tran, Zheng Miao, Jennifer Cochran, Zhen Cheng, Dean Felsher, Andreas Kjær, Juergen K. Willmann, Sanjiv S. Gambhir. PET Imaging of Tumor Neovascularization in a Transgenic Mouse Model with a Novel 64Cu-DOTA-Knottin Peptide. Cancer Res 70 (2010) 9022-30. PMID: 21062977; PMCID: PMC3057960.

8. Alfred P. See*, Jing Zeng*, Phuoc T. Tran+, and Michael Lim+. Acute toxicity of second generation HIV protease-inhibitors in combination with radiotherapy: a retrospective case series. Radiation Oncology 6 (2011) 25. PMID: 21414215; PMCID: PMC3064638. * - these authors contributed equally; and + - corresponding authors.

9. Jing Zeng, Alfred P. See, Khaled Aziz, Saravanan Thiyagarajan, Tarek Salih, Rajendra P. Gujula, Michael Armour, Jillian Phallen, Stephanie Terezakis, Lawrence Kleinberg, Kristen Redmond, Russell K. Hales, Roberto Salvatori, Alfredo Quinones-Hinojosa, Phuoc T. Tran+, Michael Lim+. Nelfinavir induces radiation sensitization in pituitary adenoma cells. Cancer Biol Ther 12 (2011) 657-63. PMID: 21811091. + - corresponding authors.

10. Phuoc T. Tran*, Pavan K. Bendapudi*, H. Jill Lin*, Peter Choi, Shan Koh, Joy Chen, George Horng, Nicholas P. Hughes, Lawrence H. Schwartz, Vincent A. Miller, Toshiyuki Kawashima, Toshio Kitamura, David Paik+ and Dean W. Felsher+. Survival and Death Signals Can Predict Tumor Response to Therapy After Oncogene Inactivation. Sci Transl Med 3 (2011) 103ra99**. PMID: 21974937. * - these authors contributed equally; and + - corresponding authors. ** - Highlighted by Comments in Sci Transl Med, Cancer Res, Nat Rev Clin Oncol and Cancer Discovery.

11. Diane Tseng*, Leeland P. Rachakonda*, Zheng Su, Ranjana Advani, Sandra Horning, Richard T. Hoppe, Andrew Quon, Edward E. Graves, Billy W. Loo, Jr, Phuoc T. Tran. Interim-treatment quantitative PET parameters predict progression and death among patients with Hodgkin's Disease. Radiation Oncology 7 (2012) 5. PMID: 22260710. * - these authors contributed equally

12. Phuoc T. Tran+, Russell K. Hales, Jing Zeng, Khaled Aziz , Tarek Salih, Rajendra P. Gajula, Sivarajan Chettiar, Nishant Gandhi, Aaron T. Wild, Rachit Kumar, Joseph M. Herman, Danny Song and Theodore L. DeWeese. Tissue Biomarkers for Prostate Cancer Radiation Therapy. Curr Mol Med 12 (2012) 772-787. PMID: 22292443; PMCID: PMC3412203. + - corresponding author.

13. Nicholas Trakul, Christine Chang, Jeremy Harris, Christopher H. Chapman, Aarti Rao, John Shen, Sean Quinlan-Davidson, Edith J. Filion, Heather Wakelee, A. Dimitrios Colevas, Richard I. Whyte, Sonja Dieterich, Peter G. Maxim, Phuoc T. Tran, Quynh-Thu Le, Billy W. Loo, Jr., Maximilian Diehn. Tumor volume-adapted dosing in stereotactic ablative radiotherapy of lung tumors. Int J Radiat Oncol Biol 84 (2012) 231-7. PMID: 22381907.

14. Phuoc T. Tran*+, Emelyn H. Shroff*, Timothy F. Burns*, Saravanan Thiyagarajan, Sandhya T. Das, Tahera Zabuawala, Joy Chen, Yoon-Jae Cho, Richard Luong, Pablo Tamayo, Tarek Salih, Khaled Aziz, Stacey J. Adam, Silvestre Vicent, Carsten H. Nielsen, Nadia Withofs, Alejandro Sweet-Cordero, Sanjiv S. Gambhir, Charles M. Rudin and Dean W. Felsher+. Twist1 suppresses senescence programs and thereby accelerates and maintains mutant Kras-induced lung tumorigenesis. PLoS Genet 8 (2012) e1002650. PMID: 22654667; PMCID: PMC3360067. * - these authors contributed equally; and + - corresponding authors.

15. Megan E. Daly, Daniel S. Kapp, Peter G. Maxim, Mark L Welton, Phuoc T. Tran, Albert C. Koong, Daniel T. Chang. Orthovoltage intraoperative radiotherapy for locally advanced and recurrent colorectal cancer. Dis Colon Rectum 55 (2012) 695-702. PMID: 22595850.

16. Somaira Nowsheen, Khaled Aziz, Phuoc T. Tran, Vassilis G. Gorgoulis, Eddy S. Yang and Alexandros G. Georgakilas. Epigenetic inactivation of DNA repair in breast cancer. Cancer Lett (2012) In press. PMID: 22634493.

17. Jing Zeng, Khaled Aziz, Sivarajan T. Chettiar, Blake Aftab, Michael Armour, Rajendra Gajula, Nishant Gandhi, Tarek Salih, Joseph M. Herman, John Wong, Charles M. Rudin, Phuoc T. Tran, Russell K. Hales. Hedgehog pathway inhibition radiosensitizes non-small cell lung cancers. Int J Radiat Oncol Biol Phy. (2012) 86 (2012) 143-149. PMID: 23182391.

18. Joseph M. Herman*, Aaron T. Wild*, Hao Wang, Phuoc T. Tran, Kenneth J. Chang, Gretchen E. Taylor, Ross C. Donehower, Timothy M. Pawlik, Mark A. Ziegler, Hongyan Cai, Dionne T. Savage, Yolanda M. Davis, Marcia I. Canto, Jason Klapman, Anthony Reid, Raj J. Shah, Sarah E Hoffe, Alexander Rosemurgy, Christopher L. Wolfgang, Daniel A. Laheru. A randomized phase III multi-institutional study of TNFerade™ biologic with 5-fluorouracil and radiotherapy for locally advanced pancreatic cancer: Final results. J Clin Oncol 31 (2013) 886-894. PMID: 23341531. * - these authors contributed equally.

19. Nishant Gandhi*, Aaron T. Wild*, Sivarajan T. Chettiar, Khaled Aziz, Yoshinori Kato, Rajendra P. Gajula, Russell D. Williams, Jessica Cades, Anvesh Annadanam, Danny Song, Yonggang Zhang, Russell K. Hales, Joseph M. Herman, Theodore L. DeWeese, Edward M. Schaeffer, Phuoc T. Tran. Novel Hsp90 inhibitor NVP-AUY922 radiosensitizes prostate cancer cells. Cancer Biol Ther 14 (2013) 347-356. PMID: 23358469. PMCID: PMC3667875. * - these authors contributed equally.

20. Timothy F. Burns, Irina Dobromilskaya, Sara C. Murphy, Rajendra P. Gajula, Saravanan Thiyagarajan, Sarah S. Chatley, Khaled Aziz, Yoon-Jae Cho, Phuoc T. Tran, Charles M. Rudin. Inhibition of TWIST1 Leads to Activation of Oncogene-Induced Senescence in Oncogene Driven Non-Small Cell Lung Cancer. Mol Cancer Res 11 (2013) 329-338. PMID: 23364532. PMCID: PMC3631276.

21. Jing Zeng, Alfred P. See, Jillian Phallen, Christopher M. Jackson, Zineb Belcaid, Jacob Ruzevick, Nicholas Durham, Christian Meyer, Timothy J. Harris, Emilia Albesiano, Gustavo Pradilla, Eric Ford, John Wong, Hans Hammers, Dimitris Mathios, Betty Tyler, Henry Brem, Phuoc T. Tran, Drew Pardoll, Charles G. Drake, Michael Lim. Anti-PD-1 blockade and stereotactic radiation produce long term survivors in mice with intracranial gliomas. Int J Radiat Oncol Biol Phys 86 (2013) 343-349. PMID: 23462419.

22. Rachit Kumar*, Aaron T. Wild*, Mark A. Ziegler, Ted K. Hooker, Samson D. Dah, Phuoc T. Tran, Jun Kang, Koren Smith, Jing Zeng, Timothy M. Pawlik, Erik Tryggestad, Eric Ford, Joseph M. Herman. Stereotactic body radiation therapy planning with duodenal sparing using volumetric modulated arc therapy versus intensity modulated radiation therapy in locally advanced pancreatic cancer: A dosimetric analysis. Med Dosim (2013) In press. PMID: 23540490. * - these authors contributed equally.

23. Aaron T. Wild, Xiaobu Ye, Susannah Ellsworth, Jessica A. Smith, Amol K. Narang, Jian Campian, Daniel A. Laheru, Lei Zheng, Christopher L. Wolfgang, Phuoc T. Tran, Stuart A. Grossman, Joseph M. Herman. The association between chemoradiation-related lymphopenia and clinical outcomes in patients with locally advanced pancreatic adenocarcinoma. Am J Clin Oncol (2013). In press. PMID: 23648440.

24. Jason A. Efstathiou, Deborah S. Nassif, Todd R. McNutt, C. Bob Bogardus, Walter Bosch, Jeff Carlin, Ron C. Chen, Henry Chou, Dave Eggert, Benedick Fraass, Joel Goldwein, Karen E. Hoffman, Ken Hotz, Margie Hunt, Marc Kessler, Colleen A. F. Lawton, Chuck Mayo, Jeff M. Michalski, Sasa Mutic, Louis Potters, Chris M. Rose, Howard M. Sandler, Greg Sharp, Wolfgang Tomé, Phuoc T. Tran, Terry Wall, Anthony L. Zietman, Peter E. Gabriel, Justin E. Bekelman. Practice-Based Evidence to Evidence-Based Practice: Building the National Radiation Oncology Registry. J Oncol Pract 9 (2013) e90-95. PMID: pending.

25. Aaron T. Wild*, Nishant Gandhi*, Sivarajan T. Chettiar, Khaled Aziz, Rajendra P. Gajula, Russell D. Williams, Rachit Kumar, Kekoa Taparra, Jing Zeng, Jessica A, Cades, Esteban Velarde, Siddharth Menon, Jean-Francois Geschwind, David Cosgrove, Timothy M. Pawlik, Anirban Maitra, John Wong, Russell K. Hales, Michael Torbenson, Joseph M. Herman, Phuoc T. Tran. Concurrent versus sequential sorafenib therapy in combination with radiation for hepatocellular carcinoma. PLoS ONE 8 (2013) e65726. PMID: 23762417. PMCID: PMC3675179. * - these authors contributed equally.

26. Sara Alcorn*, Amanda J. Walker*, Nishant Gandhi, Amol Narang, Aaron T. Wild, Russell K. Hales, Joseph M. Herman, Danny Y. Song, Theodore L. DeWeese, Emmanuel Antonarakis, Phuoc T. Tran. Molecularly Targeted Agents as Radiosensitizers in Cancer Therapy – Focus on Prostate Cancer. Int J Mol Sci 14 (2013) 14800-14832. PMID: 23863691. * - these authors contributed equally.

27. Aaron T. Wild, Susan M. Hiniker, Daniel T. Chang, Phuoc T. Tran, Mouen A. Khashab, Maneesha R. Limaye, Daniel A. Laheru, Dung Le, Rachit Kumar, Jonathan Pai, Blaire Hargens, Andrew B. Sharabi, Eun Shin, Lei Zheng, Timothy M. Pawlik, Christopher L. Wolfgang, Albert C. Koong, Joseph M. Herman. Re-irradiation with stereotactic body radiation therapy as a novel treatment option for isolated local recurrence of pancreatic cancer after multimodality therapy: Experience from two institutions. J Gastrointest Oncol (2013). In press.

28. Rajendra P. Gajula*, Sivarajan T. Chettiar*, Russell D. Williams, Saravanan Thiyagarajan, Yoshinori Kato, Khaled Aziz, Ruoqi Wang, Nishant Gandhi, Aaron T. Wild, Farhad Vesuna, Jinfang Ma, Tarek Salih, Jessica Cades, Elana Fertig, Shyam Biswal, Timothy F. Burns, Christine Chung, Charles M. Rudin, Joseph M. Herman, Russell K. Hales, Venu Raman, Steven An, Phuoc T. Tran. The Twist box is required for Twist1-induced prostate cancer metastasis. Mol Cancer Res. In press. * - these authors contributed equally.

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