Robert Ivkov Lab Research

 

Dr. Ivkov is a Visiting Assistant Professor in the Department of Radiation Oncology and Molecular Radiation Sciences. He also holds a Guest Researcher position at the National Institute of Standards and Technology’s Center for Neutron Research (NCNR) in Gaithersburg, MD. His primary research interests include the development, characterization, and use of nanomaterials to target cancer and to enhance the effectiveness of current therapies such as radiation. A specific area of research includes the study and development of selective heating with magnetic nanoparticles.

http://www.nist.gov/ncnr/

http://www.nist.gov/cnst/


Dr. Ivkov completed his formal training in Physical Chemistry at the University of Maryland, College Park with an emphasis on the thermodynamic properties of proteins. He continued to perform basic materials research at the National Institute of Standards and Technology, and later moved to the private sector to develop oncology products. Prior to his arrival to Johns Hopkins, Dr. Ivkov was Vice President of Research and Development and a co-founder of Triton BioSystems, Inc., a company developing targeted nanotherapeutics for oncology.

 

Recent Publications

 

     Nisato G., Ivkov R., Amis E. J., Size invariance of polyelectrolyte dendrimers;, Macromolecules 33, 4172-4176 (2000).

     Su T. J., Green R. J., Wang Y., Murphy E. F., Lu J. R., Ivkov R., Satija S. K., Adsorption of lysozyme onto the silicon oxide surface chemically grafted with a monolayer of pentadecyl-1-ol, Langmuir 16, 4999-5007 (2000).

     Yim H., Kent M., Matheson A., Ivkov R., Satija S. K., Majewski J., Smith G. S., Adsorption of poly(styrene sulfonate) to the air surface of water by neutron reflectivity, Macromolecules 33, 6126-6133 (2000).

     Nakatani A. I., Ivkov R., Papanek P., Yang H., Gerspacher M.; Inelastic neutron scattering from filled elastomers; Rubber Chem. and Techn., 73 , 847-863 (2000).

     Ivkov R., Papanek P., Gehring P. M., Krishnamoorti R.; Dynamics of confined polymers measured by inelastic neutron scattering; Polym. Mat. Sci. Eng. Prep. 82, 210 (2000).

     Ivkov, R., Butler, P. D., Satija, S. K., Fetters, L. K.; Effect of solvent flow on a polymer brush: A neutron reflectivity study of the brush height and chain density profile, Langmui 17, 2999 (2001).

     Zamlynny, V., Burgess, I., Szymanski, G., Lipkowski, J., Majewski, J., Smith, G., Satija, S., Ivkov, R., Electrochemical and neutron reflectivity studies of spontaneously formed amphiphilic surfactant bilayers at the gold-solution interface, Langmuir 16,9861- 9870 (2000).

     Burgess, I., Zamlynny, V., Szymanski, G., Lipkowski, J., Majewski, J., Smith, G., Satija, S., Ivkov, R., Electrochemical and neutron reflectivity characterization of dodecyl sulfate adsorption and aggregation at the gold-water interface, Langmuir 17, 3355 (2001).

     Kim, E., Suh, H. R., Kim, H., Char, K., Hong, J., Lee, S. H., Satija, S. K., Ivkov, R., Neutron reflectivity from the monolayer of SAN random copolymer; Mol. Crystals and Liq. Crystals 371, 211-214 (2001).

     Pelton R., Richardson R., Cosgrove T., Ivkov R.; The effects of temperature and methanol concentration on the properties of poly(N-isopropylacrylamide) at the air/solution interface; Langmuir 17, 5118-5120 (2001).

     Yim H., Kent M. S., Matheson A., Stevens M., Ivkov R., Satija S., Majewski J., Smith G. S., Adsorption of sodium polystyrene sulfonate at the air-surface of water by neutron reflectivity: Concentration dependence, Macromolecules, 35, 9737-9747 (2002).

     Johnson M.A., Santini C.M.B., Iyer J., Satija S., Ivkov R., Hammond P.T.; Neutron reflectivity of linear-dendritic diblock copolymer monolayers; Macromolecules 35, 231- 238 (2002).

     Ivkov R., DeNardo S. J., Daum W., Foreman A., Goldstein R., DeNardo G.L., Application of high amplitude alternating magnetic fields for heat induction of nanoparticles localized in cancer; Clin Cancer Res, 11:7093s-7103s (2005).

     DeNardo, S. J., DeNardo G.L., Miers L. A., Natarajan, A., Adamson, G. N., Gruettner, C., Ivkov R., Development of tumor targeting bioprobes (111In-chimeric L6 4 monoclonal antibody nanoparticles) for alternating magnetic field cancer therapy; Clin. Cancer Res, 11:7087s-7092s (2005).

     Norman A. I., Ivkov R., Forbes J. G., Greer S. C., The polymerization of actin: structural changes from small angle neutron scattering; J. Chem. Phys. 123(15): 154904 (2005).

     Vorotnikova E., Ivkov R., Foreman A. R., Tries M., Braunhut S. J., The magnitude and time-dependence of the apoptotic response of normal and malignant cells subjected to ionizing radiation versus hyperthermia; Int. J. Rad. Biol. 82(8), 549-559 (2006).

     DeNardo, S. J., DeNardo G.L., Natarajan, A., Miers L. A., Foreman A. R., Gruettner, C., Adamson, G. N., Ivkov R.; Thermal dosimetry predictive of efficacy of 111In-Ch L6 nanoparticle AMF induced therapy for human breast cancer in mice; J. Nucl. Med.48(3), 437- 444 (2007) Cover.

     Gruettner, C., Muller K., Teller J., Westphal F., Foreman A. R., Ivkov R.; Synthesis and antibody conjugation of magnetic nanoparticles with improved specific power absorption rates for alternating magnetic field cancer therapy; J Magnetism and Magnetic Mat., 311, 181-186 (2007).

     Hoopes P. J., Strawbridge R. R., Gibson U. J., Zeng Q., Pierce Z. E., Savellano M., Tate J. A., Ogden J. A., Baker I., Foreman A. R., Ivkov R.; Intratumoral iron oxide nanoparticle hyperthermia and radiation cancer treatment; Thermal Treatment of Tissue: Energy Delivery and Assessment IV, Proc. Of SPIE, 6440, 6440K (2007); Ed. T. P. Ryan.

     Ivkov R., DeNardo S. J., Miers L. A., Natarajan A., Gruettner C., Foreman A. R., DeNardo G. L.; Development of antibody directed nanoparticles for cancer therapy; Thermal Treatment of Tissue: Energy Delivery and Assessment IV, Proc. Of SPIE, 6440, 6440I (2007); Ed. T. P. Ryan.

     Lehmann J., Natarajan A., DeNardo G. L., Ivkov R., Foreman A. R., Catapano C., Mirick G., Gruettner C., DeNardo S. J., Nanoparticle thermotherapy and external beam radiation therapy for human prostate cancer cells, Cancer Biotherapy and Radiopharmaceuticals, 23, 265-271 (2008).

     Dennis C. L., Jackson A. J., Borchers J. A., Ivkov R., Foreman A. R., Lau J. W., Goernitz E., Gruettner C., The influence of collective behavior on the magnetic and heating properties of iron oxide nanoparticles; J. Appl. Physics 103, 07A319 (2008).

     Natarajan, A., Gruettner, C., Ivkov, R., DeNardo, G. L., Mirick, G., Yuan, A., Foreman, A., DeNardo, S. J.; NanoFerrite particle based radioimmunonanoparticles: Binding affinity and in vivo pharmacokinetics, Bioconjugate Chem., 19, 1211-1218 (2008).

     Dennis C. L., Jackson A. J., Borchers J. A., Ivkov R., Foreman A. R., Hoopes, P. J., Strawbridge, R., Pierce, Z., Goernitz, E., Lau, J. W., Gruettner, C.; The influence of magnetic and physiological behavior on the effectiveness of iron oxide nanoparticles for hyperthermia, J. Phys. D: Applied Physics 41, 1340020 (2008).

     Guistini, A., Ivkov, R., Hoopes, P.J.: An in vivo transmission electron microscopy study of injected dextran-coated iron oxide nanoparticle location in murine breast adenocarcinoma tumors versus time, Thermal Treatment of Tissue: Energy Delivery and Assessment V, Proc. Of SPIE, 7181, 71810M-1 (2009).

     Hoopes, P.J., Tate, J.A., Ogden, J.A., Strawbridge, R.R., Fiering, S.N., Petryk, A.A., Cassim, S.M., Guistini, A.J., Demidenko, E., Ivkov, R., Barry, S., Chinn, P., Foreman, A.: Assessment of intratumor non-antibody directed iron oxide nanoparticle hyperthermia cancer therapy and antibody directed IONP uptake in murine and human cells, Thermal Treatment of Tissue: Energy Delivery and Assessment V, Proc. Of SPIE, 7181, 71810P-1 (2009).

     Ogden, J.A., Tate, J.A., Strawbridge, R.R., Ivkov, R., Hoopes, P.J.: Comparison of iron oxide nanoparticle and waterbath hyperthermia cytotoxicity, Thermal Treatment of Tissue: Energy Delivery and Assessment V, Proc. Of SPIE, 7181, 71810K-1 (2009).

     Dennis C. L., Jackson A. J., Borchers J. A., Hoopes P. J., Strawbridge R. R., Foreman A. R., van Lierop J., Grüttner C., Ivkov R.; Nearly complete regression of tumors via collective behavior of magnetic nanoparticles in hyperthermia; Nanotechnology, 20, 395103 (2009)