Theodore DeWeese Lab Research

The DeWeese laboratory’s research focus is on identifying DNA repair enzymes that, if inactivated, would result in substantial radiation sensitization.  Our team has synthesized a chimeric molecule in which a siRNA-targeting DNA repair protein is combined with an aptamer targeting the prostate-unique protein, prostate specific membrane antigen (PSMA). This results in a chimeric siRNA-apatmer that is a potent, targeted radiosensitizer with potential for translation into prostate cancer therapy.